In this article, we have reviewed the current knowledge regarding the dual function of mitoribosome components in protein synthesis and apoptosis and their association with cancer susceptibility and development. We have also highlighted recent developments in targeting mitochondrial ribosomes for the treatment of cancer.
Zoe Cosner was awarded The David G. Anderson Price for outstanding University of Miami undergraduate biochemistry and molecular biology major class 2017. The award honors Dr. David G. Anderson (1923-2010), who served as undergraduate advisor for many years until his retirement in 1980. A native of South Dakota, Anderson served in the U.S. Navy during the […]
Zoe Cosner won the second place for best poster at the Life Sciences South Florida STEM undergraduate research symposium, an event showcasing undergraduate student research from 11 South Florida universities, hold in Palm Beach on April 1, 2017.
Our lab participated in the 55th Anniversary Celebration of the University of Miami Miller School of Medicine Department of Neurology, honoring the faculty’s milestones and a decade of distinguished service for our chairman Dr. Ralph Sacco. We gathered at the beautiful Biltmore Hotel in the city of Coral Gables (Miami).
Hyun-Jung Kim is visiting the laboratory of Dr. Alexey Amunts at the SciLifeLab in Stockholm (Sweden). She will learn some basics of cryo-EM and attempt reconstructing the structure of mitochondrial ribosome assembly intermediates. Andrea L. Ruetenik is visiting the laboratory of Dr. Lisa Ellerby at the Buck Institute for Research on Aging (Novato, […]
Myriam Bourens and Antoni Barrientos have published two papers on the biogenesis of human mitochondrial cytochrome c oxidase. The papers, published in EMBO Reports and the Journal of Biological Chemistry, characterize the function of two cytochrome c oxidase assembly factors, CMC1 and COX18, respectively.
Priyanka won the first place at the Research Poster Competition during the postdoctoral research day at the University of Miami. In her poster, Priyanka presented the progress on her ongoing research on the role of proteins OBGH1 and 2 on the assembly of human mitochondrial ribosomes. Her research topic, results, and presentation skills were considered as the best among […]
During the BMB Research Day at the University of Miami, Rui successfully presented the progress in her research project entitled: Assembly pathway of the yeast mitochondrial ribosome large subunit. She was awarded the first prize for best presentation.
Ph.D. Student Department of Neuroscience University of Miami Miller School of Medicine akchoi@miami.edu I work on the role of the human mitoribosome in cellular stress response
Antoni Barrientos, Ph.D., professor of neurology, has received a highly prestigious Maximizing Investigators’ Research Award (MIRA), or R35 award, from the National Institute of General Medical Sciences (NIGMS), part of the National Institutes of Health. The five-year grant, totaling more than $4.5 million, consolidates three RO1 awards and gives Barrientos the status of “NIH investigator.” […]
We used yeast and fly models of polyglutamine diseases to study how enhancement of mitochondrial function affords suppression of polyglutamine-induced cytotoxicity in the context of stress and aging.
Dasmanthie De Silva graduated in December 2015 and Ya-Ting Tu in March 2016. They are now following postdoctoral training at Berkley and Stanford, respectively.
Our labs are moving next week (9/25/15) to fully renovated space in the Neurology Research building (NRB) in the University of Miami Miller School of Medicine. In the campus map, our current building is marked with a blue cross and the new building with a red cros. Our official new address will be soon available.
Our lab has recently published review articles on two different topics. A review on “Mitochondrial Ribosome Assembly in Health and Disease” by Dasmanthie De Silva, Flavia Fontanesi, Ya-Ting Tu, Alexey Amunts and Antoni Barrientos was published in Cell Cycle. A review on “Caloric restriction, Mitochondrial Function and Aging” was published in BBA-Bioenergetics.
Zoe Cosner is an University of Miami undergraduate performing research in our laboratory with the support of the College of Arts and Sciences Summer Research Program for Underrepresented Minorities & Women (CAS) program. She has been working directly under the mentorship of Dr. Flavia Fontanesi, a Research Assistant Professor of Biochemistry and Molecular Biology. On […]
The manuscript entitled “The Human Mitochondrial DEAD-Box Protein DDX28 Resides in RNA Granules and Functions in Mitoribosome Assembly” by Ya-Ting Tu and Antoni Barrientos will be published in Cell Reports online on Feb 12 and on paper on Feb 17, 2015.
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