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Three-Lab collaborative effort to study Mitochondrial Supercomplexes

Three-Lab collaborative effort to study Mitochondrial Supercomplexes

The mitochondrial respiratory chain is organized in a dynamic set of supercomplexes (SCs). The COX7A2L protein is essential for mammalian SC III2+IV assembly. However, its function in respirasome (SCs I+III2+IVn) biogenesis remains controversial. To unambiguously determine the COX7A2L role, we generated COX7A2L-knockout (COX7A2L-KO) HEK293T and U87 cells. COX7A2L-KO cells lack SC III2+IV but have enhanced complex III steady-state levels, activity, […]

The RNA Club at UM is back!

The RNA Club at UM is back!

Following a couple of years of rest, the RNA Club organized by Dr. Murray Deutscher (Department of Biochemistry and Molecular Biology) and Dr. Antoni Barrientos is back. The first presentation will take place on November 14, 2018. Title: “The human Obg-family GTPase GTPBP10 is required for mitochondrial ribosome maturation” Presenter: Dr. Priyanka Maiti; Introduction to the […]

Priyanka reports the function of the human ObG-family GTPase GTPBP10 in mitochondrial ribosome maturation

Priyanka reports the function of the human ObG-family GTPase GTPBP10 in mitochondrial ribosome maturation

Most steps on the biogenesis of the mitochondrial ribosome (mitoribosome) occur near the mitochondrial DNA nucleoid, in RNA granules, which contain dedicated RNA metabolism and mitoribosome assembly factors. Here, analysis of the RNA granule proteome identified the presence of a set of small GTPases that belong to conserved families of ribosome assembly factors. We show […]

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