Welcome
The main research interest of our lab is on the basic mechanisms that govern the biogenesis of mitochondrial protein complexes in health, disease and aging. We are most specifically interested in the assembly and function of the mitochondrial translation machinery and of the mitochondrial respiratory chain and oxidative phosphorylation system components, involved in biological energy transduction.
The study of mitochondria is now a very “hot issue” for both basic and clinical research. Mitochondria are not only the “energy factories” of the cell but they also house a multiplicity of pathways that serve to regulate cellular life and death. Importantly, mitochondria are involved in prevalent human diseases of wide social impact, most notably neurodegenerative disorders, but also in cancer and the aging process.
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News
2021-Meredith publishes a new paper on yeast models of neurodegenerative proteotoxicity
We have a new manuscript published in Human Molecular Genetics showing that several NAD+ biosynthetic enzymes moonlight as molecular chaperones to combat proteotoxicity. The links below will take you to the University of Miami announcement page: https://nam10.safelinks.protection.outlook.com/?url=https%3A%2F%2Fphysician-news.umiamihealth.org%2Fnervous-yeast-helps-identify-targets-for-fighting-neurodegeneration%2F&data=04%7C01%7CABarrientos%40med.miami.edu%7Cc5770afc1bb04ccfa6c008d953810576%7C2a144b72f23942d48c0e6f0f17c48e33%7C0%7C0%7C637632635888236167%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C1000&sdata=8QkBA%2Fqca6vtyOvNL6nxV7neewxA7V4muJcYLId4vAo%3D&reserved=0 and to the Human Molecular Genetics page: https://watermark.silverchair.com/ddab080.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAAuAwggLcBgkqhkiG9w0BBwagggLNMIICyQIBADCCAsIGCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQM6Qbd6NTMR8uZSEzAAgEQgIICkyNstTwC9A7Rgzxfjd-xORifTsnqDJSv8HDveAvQb62fyVoNtfk3MWyPSEufyEszPbg2lt62-wmqdbtptaf2jlRZOKK-pkLcGSbiM5j4rpLVL-sp5NiaT7hZ3qVLcyREYvpE4NSs-2MA91h2go1m5CswmHZ3sI3JAiM2uxQdbKyo2LPkYc-MHQ9J_idfF2CwEAmCeCgYaXtmks_G-w9ZYcDKTaRBod_D7vuTCQboV6do9YngvD0yBxIZHw40UpATWFClnYnVRQhSctZYtKNEoIG_hDM1tWKeQmCOx5mn605OiQua61Fv9veQp3-BpkHEajoGINSTQ3ZjqKh8qKr2QmNXQgGwxkN5FMuclep2uP16Q118tWSEIcRZSEJ08R0GMHNAM0Vo1tQZRg1lt1oO5A2H-N0s36RCzBype07gmq6z3tMYowBiZTJ2Pq_2XPEpSBobaYuP0OzaYII3QN0Kz1Bldi6z_xyFeXAdDfWp4-LFfAlT3_HKBjPbKaNJTU07qk2CqD_UWSXa02gPB7ZT71PiSf5PmCItPCzjWdSLP8LcE4E7h_A9Yqy2Yh5szr4BRkseZvPf_WyXRTvuXiUdM7r_bbjdgJSG_IGlus47XOg777DXWjv8hv1WfPHfSVq5qAcQI2wQB-mnMVXrhSb8_CSZSui3ETc3OH7_LF6rzhEXu-jpjMPrS6wpqVdiX5UyMlnldYJoMzr-A2W4wVUquzDU4QCrp9I2o-kzjzT0jLV7ZeNsgN7-dxeY4M-Ou-kIlpxf8At5zKqkANCWCoMismwBMDNcCaQ2vhtY5gh22WxpBuj_VZZn1FRs5Oalmf8V8y-b18BjGJp3IcQwPfI5hU9A2NhbyYc1vEDy7A6ZweYx8SzI
