We are excited to share that our group has published an article in Nucleic Acids Research about TACO1, a mitochondrial protein linked to a form of Leigh syndrome. In this study, led by Dr. Michele Brischigliaro as the first author, we describe TACO1’s role in facilitating mitochondrial translation by alleviating mitoribosome stalling during the synthesis […]
Dr. Michele Brischigliaro has been awarded a Development Grant from the Muscular Dystrophy Association (MDA) to investigate the role of aberrant mt-mRNA folding in mitochondrial encephalomyopathies. This well-deserved recognition highlights Michele’s innovative research and marks an important milestone on his journey toward establishing an independent scientific career. Congratulations, Michele, on this remarkable achievement!
Our group, with Dr. Conor Moran as the first author, has published a collaborative study with Harvard that advances our understanding of mitochondrial mRNA structure. This research underscores the critical role of maintaining mitochondrial mRNA folding, demonstrated using a cell line deficient in the leucine-rich pentatricopeptide repeat–containing protein (LRPPRC). LRPPRC acts as a holdase, stabilizing […]
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