This November, Michele and Toni embarked on a two-week visit to the labs of Dr. Joanna Rorbach and Dr. Nils Larsson at the prestigious Karolinska Institute in Sweden. Despite the freezing temperatures, the experience proved to be incredibly rewarding. The collaboration facilitated an exchange of techniques, enhancing the technical expertise of both research groups and […]
We are excited to share that our group has published an article in Nucleic Acids Research about TACO1, a mitochondrial protein linked to a form of Leigh syndrome. In this study, led by Dr. Michele Brischigliaro as the first author, we describe TACO1’s role in facilitating mitochondrial translation by alleviating mitoribosome stalling during the synthesis […]
Dr. Michele Brischigliaro has been awarded a Development Grant from the Muscular Dystrophy Association (MDA) to investigate the role of aberrant mt-mRNA folding in mitochondrial encephalomyopathies. This well-deserved recognition highlights Michele’s innovative research and marks an important milestone on his journey toward establishing an independent scientific career. Congratulations, Michele, on this remarkable achievement!
Our group, with Dr. Conor Moran as the first author, has published a collaborative study with Harvard that advances our understanding of mitochondrial mRNA structure. This research underscores the critical role of maintaining mitochondrial mRNA folding, demonstrated using a cell line deficient in the leucine-rich pentatricopeptide repeat–containing protein (LRPPRC). LRPPRC acts as a holdase, stabilizing […]
This year, the Barrientos Lab attended the prestigious Gordon Research Conference in Barcelona, focused on cutting-edge advancements in mitochondrial and chloroplast research. Scientists from around the world gathered to present and discuss their latest findings. We are especially proud that our group leader, Dr. Barrientos, served as one of the conference chairs, making this event […]
We have a new manuscript published in Human Molecular Genetics showing that several NAD+ biosynthetic enzymes moonlight as molecular chaperones to combat proteotoxicity. The links below will take you to the University of Miami announcement page: https://nam10.safelinks.protection.outlook.com/?url=https%3A%2F%2Fphysician-news.umiamihealth.org%2Fnervous-yeast-helps-identify-targets-for-fighting-neurodegeneration%2F&data=04%7C01%7CABarrientos%40med.miami.edu%7Cc5770afc1bb04ccfa6c008d953810576%7C2a144b72f23942d48c0e6f0f17c48e33%7C0%7C0%7C637632635888236167%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C1000&sdata=8QkBA%2Fqca6vtyOvNL6nxV7neewxA7V4muJcYLId4vAo%3D&reserved=0 and to the Human Molecular Genetics page: https://watermark.silverchair.com/ddab080.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAAuAwggLcBgkqhkiG9w0BBwagggLNMIICyQIBADCCAsIGCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQM6Qbd6NTMR8uZSEzAAgEQgIICkyNstTwC9A7Rgzxfjd-xORifTsnqDJSv8HDveAvQb62fyVoNtfk3MWyPSEufyEszPbg2lt62-wmqdbtptaf2jlRZOKK-pkLcGSbiM5j4rpLVL-sp5NiaT7hZ3qVLcyREYvpE4NSs-2MA91h2go1m5CswmHZ3sI3JAiM2uxQdbKyo2LPkYc-MHQ9J_idfF2CwEAmCeCgYaXtmks_G-w9ZYcDKTaRBod_D7vuTCQboV6do9YngvD0yBxIZHw40UpATWFClnYnVRQhSctZYtKNEoIG_hDM1tWKeQmCOx5mn605OiQua61Fv9veQp3-BpkHEajoGINSTQ3ZjqKh8qKr2QmNXQgGwxkN5FMuclep2uP16Q118tWSEIcRZSEJ08R0GMHNAM0Vo1tQZRg1lt1oO5A2H-N0s36RCzBype07gmq6z3tMYowBiZTJ2Pq_2XPEpSBobaYuP0OzaYII3QN0Kz1Bldi6z_xyFeXAdDfWp4-LFfAlT3_HKBjPbKaNJTU07qk2CqD_UWSXa02gPB7ZT71PiSf5PmCItPCzjWdSLP8LcE4E7h_A9Yqy2Yh5szr4BRkseZvPf_WyXRTvuXiUdM7r_bbjdgJSG_IGlus47XOg777DXWjv8hv1WfPHfSVq5qAcQI2wQB-mnMVXrhSb8_CSZSui3ETc3OH7_LF6rzhEXu-jpjMPrS6wpqVdiX5UyMlnldYJoMzr-A2W4wVUquzDU4QCrp9I2o-kzjzT0jLV7ZeNsgN7-dxeY4M-Ou-kIlpxf8At5zKqkANCWCoMismwBMDNcCaQ2vhtY5gh22WxpBuj_VZZn1FRs5Oalmf8V8y-b18BjGJp3IcQwPfI5hU9A2NhbyYc1vEDy7A6ZweYx8SzI
Follow the link to the note in the UM magazine: https://physician-news.umiamihealth.org/dissecting-our-cellular-power-plants/
January 11-13, 2021, Meredith attended the SfN Global Connectome Meeting, where she presented a poster entitled “NAD+ biosynthetic pathway enzymes: Potential therapeutic targets for age-related neurodegeneration”.
Conor is being instrumental for the project and the collaboration with Silvi’s lab
Visit:https://chanzuckerberg.com/science/programs-resources/neurodegeneration-challenge/projects/the-mitochondrial-rna-structurome-as-mediator-of-neurological-disease/
Read the News is posted on InventUM. https://physician-news.umiamihealth.org/protein-complex-assembly-mechanisms-shed-light-on-cellular-energy-plants/
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