News

2021-Alba receives a development grant from the Muscular Dystrophy Association (MDA)

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2021-Conor receives an F30 NIH predoctoral fellowship award

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2021-Meredith publishes a new paper on yeast models of neurodegenerative proteotoxicity

2021-Meredith publishes a new paper on yeast models of neurodegenerative proteotoxicity

We have a new manuscript published in Human Molecular Genetics showing that several NAD+ biosynthetic enzymes moonlight as molecular chaperones to combat proteotoxicity. The links below will take you to the University of Miami announcement page: https://nam10.safelinks.protection.outlook.com/?url=https%3A%2F%2Fphysician-news.umiamihealth.org%2Fnervous-yeast-helps-identify-targets-for-fighting-neurodegeneration%2F&data=04%7C01%7CABarrientos%40med.miami.edu%7Cc5770afc1bb04ccfa6c008d953810576%7C2a144b72f23942d48c0e6f0f17c48e33%7C0%7C0%7C637632635888236167%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C1000&sdata=8QkBA%2Fqca6vtyOvNL6nxV7neewxA7V4muJcYLId4vAo%3D&reserved=0 and to the Human Molecular Genetics page: https://watermark.silverchair.com/ddab080.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAAuAwggLcBgkqhkiG9w0BBwagggLNMIICyQIBADCCAsIGCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQM6Qbd6NTMR8uZSEzAAgEQgIICkyNstTwC9A7Rgzxfjd-xORifTsnqDJSv8HDveAvQb62fyVoNtfk3MWyPSEufyEszPbg2lt62-wmqdbtptaf2jlRZOKK-pkLcGSbiM5j4rpLVL-sp5NiaT7hZ3qVLcyREYvpE4NSs-2MA91h2go1m5CswmHZ3sI3JAiM2uxQdbKyo2LPkYc-MHQ9J_idfF2CwEAmCeCgYaXtmks_G-w9ZYcDKTaRBod_D7vuTCQboV6do9YngvD0yBxIZHw40UpATWFClnYnVRQhSctZYtKNEoIG_hDM1tWKeQmCOx5mn605OiQua61Fv9veQp3-BpkHEajoGINSTQ3ZjqKh8qKr2QmNXQgGwxkN5FMuclep2uP16Q118tWSEIcRZSEJ08R0GMHNAM0Vo1tQZRg1lt1oO5A2H-N0s36RCzBype07gmq6z3tMYowBiZTJ2Pq_2XPEpSBobaYuP0OzaYII3QN0Kz1Bldi6z_xyFeXAdDfWp4-LFfAlT3_HKBjPbKaNJTU07qk2CqD_UWSXa02gPB7ZT71PiSf5PmCItPCzjWdSLP8LcE4E7h_A9Yqy2Yh5szr4BRkseZvPf_WyXRTvuXiUdM7r_bbjdgJSG_IGlus47XOg777DXWjv8hv1WfPHfSVq5qAcQI2wQB-mnMVXrhSb8_CSZSui3ETc3OH7_LF6rzhEXu-jpjMPrS6wpqVdiX5UyMlnldYJoMzr-A2W4wVUquzDU4QCrp9I2o-kzjzT0jLV7ZeNsgN7-dxeY4M-Ou-kIlpxf8At5zKqkANCWCoMismwBMDNcCaQ2vhtY5gh22WxpBuj_VZZn1FRs5Oalmf8V8y-b18BjGJp3IcQwPfI5hU9A2NhbyYc1vEDy7A6ZweYx8SzI

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2021-Austin got his Ph.D.!

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2021-Protein delivery by the mitoribosome: a great story by an international team of collaborators

2021-Protein delivery by the mitoribosome: a great story by an international team of collaborators

Follow the link to the note in the UM magazine: https://physician-news.umiamihealth.org/dissecting-our-cellular-power-plants/

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Meredith Pinkerton presents at the SfN Global Connectome 2021

Meredith Pinkerton presents at the SfN Global Connectome 2021

January 11-13, 2021, Meredith attended the SfN Global Connectome Meeting, where she presented a poster entitled “NAD+ biosynthetic pathway enzymes: Potential therapeutic targets for age-related neurodegeneration”.

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2020-Conor Moran, M.D./Ph.D. student, visits Silvi Rouskin at the Whitehead as part of the CZI collaboration

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2020-Antoni Barrientos and Silvi Rouskin awarded CZI funding to tackle questions regarding mitochondrial encephalomyopathies

2020-Antoni Barrientos and Silvi Rouskin awarded CZI funding to tackle questions regarding mitochondrial encephalomyopathies

    Visit:https://chanzuckerberg.com/science/programs-resources/neurodegeneration-challenge/projects/the-mitochondrial-rna-structurome-as-mediator-of-neurological-disease/  

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2020-Flavia (new tenure-track Assistant Professor of BMB) publishes on a novel mechanism of mitochondrial translation regulation

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Alba publishes in Cell Reports on the role of HIGD1A and HIGD2A on mitochondrial respiratory chain complex and supercomplex biogenesis

Alba publishes in Cell Reports on the role of HIGD1A and HIGD2A on mitochondrial respiratory chain complex and supercomplex biogenesis

Read the News is posted on InventUM.    https://physician-news.umiamihealth.org/protein-complex-assembly-mechanisms-shed-light-on-cellular-energy-plants/

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Hyun-Jung received a 2020 U.M. Medical Faculty Association Award for Best Research

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Dr. Flavia Fontanesi publishes in NAR

Dr. Flavia Fontanesi publishes in NAR

Flavia Fontanesi directed the work of  Jeffri-Noelle Mays and led a three-lab collaborative effort that resulted in the publication on a paper in Nucleic Acids Research. The paper, entitled “The mitoribosome-specific protein mS38 is preferentially required for synthesis of cytochrome c oxidase subunits” can be found at https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkz266/5436776 Authors: Jeffri-Noelle Mays, Yolanda Camacho-Villasana, Rodolfo Garcia-Villegas, Xochitl Perez-Martinez, Antoni […]

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Tania Perez receives the ASB Meeting Oral Presentation Award

Tania Perez receives the ASB Meeting Oral Presentation Award

Tania Perez recently attended the 2019 Meeting of the Association of Southeastern Biologists (ASB) where she completed an oral presentation titled “Investigating the Assembly Pathway for the Yeast Mitoribosomal Small Subunit” in the Cell and Molecular Biology category. She was awarded the Lafayette Frederick Underrepresented Minorities Scholarship–which supported her attendance of the conference. Furthermore, Tania […]

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Priyanka and Eva received AHA postdoctoral fellowship awards

Priyanka and Eva received AHA postdoctoral fellowship awards

Congrats to Dr. Eva Nyvltova and Dr. Priyanka Maiti, who received postdoctoral fellowships from the American Heart Association (AHA).

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Tania wins the Best poster presentation award at the ABRCMS 2018 Symposium

Tania wins the Best poster presentation award at the ABRCMS 2018 Symposium

Congratulations to Tania Perez, who did an outstanding job presenting her work on the assembly pathway of the small ribosomal subunit in the yeast Saccharomyces cerevisiae.

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Three-Lab collaborative effort to study Mitochondrial Supercomplexes

Three-Lab collaborative effort to study Mitochondrial Supercomplexes

The mitochondrial respiratory chain is organized in a dynamic set of supercomplexes (SCs). The COX7A2L protein is essential for mammalian SC III2+IV assembly. However, its function in respirasome (SCs I+III2+IVn) biogenesis remains controversial. To unambiguously determine the COX7A2L role, we generated COX7A2L-knockout (COX7A2L-KO) HEK293T and U87 cells. COX7A2L-KO cells lack SC III2+IV but have enhanced complex III steady-state levels, activity, […]

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