Following two years of work, Dasmanthie has obtained a 3rd-year renewal of her fellowship to study the role of the DEAD box helicase Mrh4 in mitoribosome assembly.
This is a multiple PI grant, in which Dr. Barrientos and Dr. Cristina Ugalde (Hospital 12 de Octubre, Madrid, Spain) join forces to study the assembly pathway of mitochondrial respirasomes.
“The DEAD box protein Mrh4 functions in the assembly of the mitochondrial large ribosomal subunit” by Dasmanthie De Silva, Flavia Fontanesi and Antoni Barrientos. Mitochondria contain their own ribosomes, which specialize in the synthesis of a handful of proteins required for oxidative phosphorylation. The pathway of mitoribosomal biogenesis and factors involved are poorly characterized. Here, […]
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