Juried or Refereed Journal Articles

Public URL for “my bibliography” collection in My NCBI is: http://www.ncbi.nlm.nih.gov/sites/myncbi/antoni.barrientos.1/bibliography/41138774/public/?sort=date&direction=ascending. There you can find a complete list of publications.

  1. Soto I and Barrientos A. Cytochrome c Oxidase Biogenesis is Regulated by the Redox State of a Heme-Binding Translational Activator.  Antiox Redox Signal (2015)
  2. Tu YT and Barrientos A. The human mitochondrial DEAD-Box protein DDX28 resides in RNA granules and functions in mitoribosome assembly. Cell Reports. 10: 854-64 (2015)
  3. Abrams AJ, Hufnagel RB, Rebelo A, Zanna C, Patel N, Gonzalez MA, Campeanu IJ, Griffin LB, Groenewald S, Strickland AV, Tao F, Speziani F, Abreu L, Schüle R, Caporali L, La Morgia C, Maresca A, Liguori R, Lodi R, Ahmed ZM, Sund KL, Wang X, Krueger LA, Peng Y, Prada CE, Prows CA, Schorry EK, Antonellis A, Zimmerman HH, Abdul-Rahman OA, Yang Y, Downes SM, Prince J, Fontanesi F, Barrientos A, Németh AH, Carelli V, Huang T, Zuchner S, Dallman JE. Mutations in SLC25A46, encoding a UGO1-like protein, cause an optic atrophy spectrum disorder. Nat Genet. 47(8):926-32 (2015)
  4. Tigano M, Ruotolo R, Dallabona C, Fontanesi F, Barrientos A, Donnini C, and Ottonello S. (2015). Elongator-dependent modification of cytoplasmic tRNALysUUU is required for mitochondrial function under stress conditions. Nuc Ac Res. July 2015. [Epub ahead of time].
  5. Ruetenik AL and Barrientos A. Dietary restriction, mitochondrial function and aging: from yeast to humans. BBA: Bioenergetics. 1847 (2015) 14341447 (20015)
  6. De Silva D, Tu YT, Amunts A, Fontanesi F, Barrientos A.  Mitochondrial ribosome assembly in health and disease. Cell Cycle. 14(14):2226-50 (2015)
  7. Neal SE, Dabir DV, Tienson HL, Horn DM, Glaeser K, Ogozalek Loo RR, Barrientos A, Koehler CM. Mia40 serves as an electron sink in the Mia40-Erv1 import pathway. J Biol Chem290(34):20804-14 (2015)
  8. Barrientos A (2015) Mitochondriolus: assembling mitoribosomes. Oncotarget 6(19):16800-1 (2015)
  9. Hess KC, Liu J, Manfredi G, Mühlschlegel FA, Buck J, Levin LR, Barrientos A. A mitochondrial CO2-adenylyl cyclase-cAMP signalosome controls yeast normoxic cytochrome c oxidase activity. FASEB J. 28: 4369-80 (2014)
  10. Bourens M, Boulet A, Leary SC, Barrientos A. Human COX20 cooperates with SCO1 and SCO2 to mature COX2 and promote the assembly of cytochrome c oxidase. Mol. Genet. 23(11): 2901-13 (2014)
  11. De Silva D, Fontanesi F and Barrientos A. The DEAD-Box protein Mrh4 functions in the assembly of the mitochondrial large ribosomal subunit. Cell Metab. 18: 712-25 (2013)
  12. Patel N, Barrientos A, Landgraf R. The Growth Factor Receptor ERBB2 regulates Mitochondrial Activity on a Signaling Timescale. Biol. Chem. 288: 35253-65 (2013)
  13. Samuli Kursu VA, Pietikäinen LP, Fontanesi F, Aaltonen MJ, Suomi F, Raghavan Nair R, Schonauer MS, Dieckmann CL, Barrientos A, Hiltunen JK, Kastaniotis AJ. Defects in mitochondrial fatty acid synthesis result in failure of multiple aspects of mitochondrial biogenesis in Saccharomyces cerevisiae. Microbiol. 90: 824-40 (2013)
  14. Lu G, Matsuura SE, Barrientos A, Scott WA. HIV-1 Infection Is Blocked at an Early Stage in Cells Devoid of Mitochondrial DNA. PLoS One. 2013 8(10):e78035 (2013)
  15. Barrientos A and Ugalde C. I function, therefore I am: overcoming doubt about mitochondrial supercomplexes. Cell Metab. July 18(2):147-9 (2013)
  16. Ocampo A, Liu JJ and Barrientos A. NAD+ salvage pathway proteins suppress proteotoxicity in yeast models of neurodegeneration. Mol. Genet. 22(9):1699-708 (2013)
  17. Clemente P, Peralta S, Cruz-Bermudez A, Echevarria L, Fontanesi F, Barrientos A, Fernandez-Moreno MA, Garesse R. hCOA3 stabilizes COX1 and promotes cytochrome c oxidase assembly in human mitochondria. Biol. Chem. 288(12):8321-31 (2013)
  18. Bourens M, Fontanesi F, Soto IC, Liu J, and Barrientos A. Reactive Oxygen Species and Redox Regulation of Mitochondrial Cytochrome c Oxidase Biogenesis. Antiox. Redox Signal. 19(16):1940-52 (2013)
  19. Liu J and Barrientos A. Transcriptional regulation of yeast OXPHOS hypoxic genes by oxidative stress. AntioxRedox Signal. 19(16):1916-27 (2013)
  20. Soto IC, Fontanesi F, Myers RS, Hamel P and Barrientos A. A Heme-Sensing Mechanism in the Translational Regulation of Mitochondrial Cytochrome c Oxidase Biogenesis. Cell Metab. 16 (6): 801-813 (2012)
  21. Barrientos A. Complementary roles of mitochondrial respiration and ROS signaling on cellular aging and longevity. Aging 4(9): 1-2 (2012)
  22. Bourens M, Dabir DV, Tienson HL, Sorokina, I, Koehler CM and Barrientos A. Role of twin-CysX9Cys motif cysteines in mitochondrial import of the cytochrome c oxidase biogenesis factor Cmc1. J Biol Chem 287(37):31258-69 (2012)
  23. Ocampo A, Liu JJ, Schroeder EA, Shadel GS and Barrientos A. Mitochondrial respiratory thresholds regulate yeast chronological life span and its extension by caloric restriction. Cell Metab. 16(1):55-67 (2012)
  24. Moreno-Lastres D, Fontanesi F, García-Consuegra I, Martín MA, Arenas J, Barrientos A, Ugalde C. Mitochondrial Complex I plays an Essential Role in Human Respirasome Assembly. Cell Metab. 15(3):324-35 (2012)
  25. Soto IC, Fontanesi F, Liu J, Barrientos Biogenesis and assembly of eukaryotic cytochrome c oxidase catalytic core. Biochim. Biophys. Acta. 1817(6):883-97 (2012)
  26. Ocampo A and Barrientos A. Developing yeast models of human neurodegenerative disorders. Methods Mol. Biol. 793: 113-127 (2011)
  27. Yong Pan Y, Schroeder EA, Ocampo A, Barrientos A and Shadel GS. Regulation of yeast chronological life span by TORC1 via adaptive mitochondrial ROS signaling. Cell Metab. 13(6): 668-678 (2011)
  28. Ocampo A and Barrientos A. Quick and reliable assessment of chronological life span in yeast cell populations by flow cytometry. Ageing. Dev. 132: 315-323 (2011)
  29. Fontanesi F, Clemente P, Barrientos A. Cox25 teams up with Mss51, Ssc1 and Cox14 to regulate mitochondrial cytochrome c oxidase subunit 1 expression and assembly in Saccharomyces cerevisiae. Biol. Chem. 286(1):255-266 (2011)
  30. Horn D, Zhou W, Trevisson E, Al-Ali H, Harris TK, Salviati L, and Barrientos A. The conserved mitochondrial twin CX9C protein Cmc2 is a Cmc1 homologue essential for cytochrome c oxidase biogenesis. Biol. Chem. 285(20):15088-99 (2010)
  31. Fontanesi F., Soto I.C., Horn D., Barrientos A. Mss51 and Ssc1 facilitate translational regulation of cytochrome c oxidase biogenesis. Mol Cell Biol. 30: 245-259 (2010)
  32. Ocampo A, Zambrano A. and Barrientos A. Suppression of polyglutamine-induced cytotoxicity in Saccharomyces cerevisiae by enhancement of mitochondrial biogenesis. FASEB J. 24(5):1431-41 (2010)
  33. Soto IC, Fontanesi F, Valledor M, Horn D, Singh R. and Barrientos A. Synthesis of cytochrome c oxidase subunit 1 is translationally down-regulated in the absence of functional F1F0-ATP synthase. Biophys. Acta (Mol. Cell. Res.) 1793:1776-86 (2009)
  34. Barrientos A, Gouget K, Horn D, Soto IC and Fontanesi F. Suppression mechanisms of COX assembly defects in yeast and human: Insights into the COX assembly process. Biophys. Acta. (Mol. Cell. Res.) 1793:97-107 (2009)
  35. Perales-Clemente E, Bayona-Bafaluy P, Pérez-Martos A, Barrientos A., Fernández-Silva P, and Enríquez JA. Restoration of electron transport without proton pumping in mammalian mitochondria. N.A.S 105: 18735-18739 (2008)
  36. Ocampo A and Barrientos A. From the bakery to the brain business: developing inducible yeast models of human neurodegenerative disorders. Biotechniques 45(4):Pvii-xiv (2008)
  37. Horn D, Al-Ali H, and Barrientos A. Cmc1p is a conserved mitochondrial twin Cx9C protein Involved in cytochrome c oxidase biogenesis. Cell. Biol. 28:4354-64 (2008)
  38. Horn D and Barrientos A. Mitochondrial copper metabolism and delivery to cytochrome c IUBMB Life. 60:421-9 (2008)
  39. Fontanesi F, Soto IC and Barrientos A. Cytochrome c oxidase biogenesis: new levels of regulation. IUBMB Life. 60:557-68 (2008)
  40. Fontanesi F., Jin C., Tzagoloff A., and Barrientos A. Transcriptional Activators HAP/NF-Y Rescue a Cytochrome c Oxidase Defect in Yeast and Human Cells. Hum Mol Genet. 17:775-88 (2008)
  41. Dave K.R., DeFazio R.A., Raval AP, Torraco A, Saul I, Barrientos A and Perez-Pinzon M.A. Ischemic preconditioning targets the respiration of synaptic mitochondria via protein kinase c Epsilon. Neurosc. 28: 4172-4182 (2008)
  42. Wiley DJ, Catanuto P,Fontanesi F, Rios C, Sanchez N, Barrientos, and VerdeF. Bot1p is required for mitochondrial translation, respiratory function and normal cell morphology in the fission yeast Schizosaccharomyces pombe. Eukaryotic Cell, 7: 619-29 (2008)
  43. Jin C, Barrientos A, Epstein CB, Butow RA, and Tzagoloff A. SIT4 regulation of Mig1p-mediated catabolite repression in Saccharomyces cerevisiae. FEBS Lett. 581:5658-63 (2007)
  44. Zambrano A, Fontanesi F, Solans A, de Oliveira RL, Fox TD, Tzagolof A, Barrientos A. Aberrant translation of cytochrome c oxidase subunit 1 mRNA species in the absence of Mss51p in the yeast Saccharomyces cerevisiae. Biol. Cell. 18:523-35. (2007)
  45. Vempati UD, Diaz F, Barrientos A, Narisawa S, Mian AM, Millan JL, Boise LH, Moraes C.T. Role of cytochrome c in apoptosis: increased sensitivity to tumor necrosis factor alpha is associated with respiratory defects but not with lack of cytochrome c release. Cell Biol. 27(5):1771-83. (2007)
  46. Solans A., Zambrano A., Rodriguez M., and Barrientos A. Cytotoxicity of a mutant huntingtin fragment in yeast involves early alterations in mitochondrial OXPHOS complex II and III. Mol. Genet., 15(20):3063-81. (2006)
  47. Fontanesi F, Soto IC, Horn D, and Barrientos A. Assembly of mitochondrial cytochrome c oxidase, a complicated and highly regulated cellular process. J. Physiol. – Cell Physiol., 291(6):C1129-47. (2006)
  48. Moraes CT, Diaz F, and Barrientos A. Defects in the biosynthesis of mitochondrial heme c and heme a in yeast and mammals Biophys. Acta – Bioenergetics, 1659: 153-159. (2005)
  49. Barrientos A, Zambrano A., and Tzagoloff A. Mss51p and Cox14p jointly regulate mitochondrial Cox1p expression in Saccharomyces cerevisiae. EMBO J. 23(17):3472-82. (2004)
  50. Solans A, Zambrano A, and Barrientos A. Cytochrome c oxidase deficiency: from yeast to human Preclinica. 2(5):336-348 (2004)
  51. Tzagoloff A, Barrientos A, Neupert W, Herrmann JM. Atp10p assists assembly of Atp6p into the F0 unit of the yeast mitochondrial ATPase Biol. Chem. 279: 19775-80 (2004)
  52. Barrientos A. Yeast models of human mitochondrial diseases IUBMB Life. 55:83-95. (2003)
  53. Barrientos A, Korr D, Barwell KJ, Christian Sjulsen C, Gajewski CD, Manfredi G, Sharon Ackerman S, and Tzagoloff A. MTG1 codes for a conserved protein required for mitochondrial translation Biol. Cell 14:2292-302. (2003)
  54. Jin C, Barrientos A, and Tzagoloff A. Yeast dihydroxybutanone phosphate synthase, an enzyme of the riboflavin biosynthetic pathway has a second unrelated function in expression of mitochondrial respiration Biol. Chem. 278:14698-703. (2003)
  55. Barrientos A, Pierre D, Lee J, and Tzagoloff A. Cytochrome oxidase assembly does not require catalytically active cytochrome J. Biol. Chem. 278:8881-7. (2003)
  56. Carlson C.G., Barrientos A., Tzagoloff A., and Glerum D.M. COX16 encodes a novel protein required for the assembly of cytochrome oxidase in Saccharomyces cerevisiae Biol. Chem. 278: 3770-5. (2002)
  57. Ludovico P, Rodrigues F, Almeida A, Silva MT, Barrientos A. and Côrte-Real, M. Cytochrome c release and mitochondria involvement in programmed cell death induced by acetic acid in Saccharomyces cerevisiae Biol. Cell 13:2598-606. (2002)
  58. Barrientos A. In vivo and in organello assessment of OXPHOS activities A companion of Methods Enzymol. 26: 307-16. (2002)
  59. Barrientos A, Barros M, Valnot I, Rotig A, Rustin P, and Tzagoloff A. Cytochrome oxidase in health and disease Gene. 286(1): 53-63. (2002)
  60. Barrientos A, Korr D, and Tzagoloff A. Mitochondrial cytochrome c oxidase assembly: Shy1p is necessary for full expression of subunit 1 in the yeast model of Leigh’s syndrome EMBO J. 21(1-2): 43-52. (2002)
  61. D’Aurelio M, Pallotti F, Barrientos A, Gajewski CD, Kwong JQ, Bruno C, Beal MF, Manfredi G. In vivo regulation of oxidative phosphorylation in cells harboring a stop-codon mutation in mitochondrial DNA-encoded cytochrome c oxidase subunit I Biol. Chem. 276(50): 46925-32. (2001)
  62. de Lonlay P, ValnotI, Barrientos A, Gorbatyuk, TzagoloffA, BenayounE, ChrétienD, KadhomN, LombèsA, Ogier de BaulnyH, NiaudetP, RustinP, MunnichA and RötigA Mutations in BCS1, a mitochondral respiratory chain assembly gene, are responsible for the complex III deficiency of patients with fatal tubulophathy and liver failure Nat. Genet. 29: 57-60. (2001)
  63. Barrientos A, Dey R, Müller S, Wienberg J, and Moraes CT Cytochrome c oxidase assembly in primates is extremely sensitive to evolutionary variations in amino acid sequence Biol. Evol. 17: 1508-1519. (2000)
  64. Paul MF, Barrientos A, Tzagoloff A. A single amino acid change in subunit 6 of the yeast mitochondrial ATPase suppresses a null mutation in ATP10 Biol. Chem. 275: 29238-43. (2000)
  65. Dey R., Barrientos A. and Moraes C.T. Functional Constraints of Nuclear – Mitochondrial DNA Interactions in Xenomitochondrial Rodent Cell Lines Biol. Chem. 275:31520-31527. (2000)
  66. Valnot I., Kleist-Retzow J.-C., Barrientos A., Gorbatyuk M., Rustin P., Tzagoloff A., Munnich A., and Rötig A. Mutation in the haem A:Farnesyl transferase (COX10) gene in cytochrome c oxidase deficiency Mol. Genet. 9:1245-9. (2000)
  67. Jarreta D., Orus J., Barrientos A., Miró O, Roig E., Heras M., Moraes, C.T., Cardellach F. and Casademont J. Mitochondrial function in heart muscle from patients with idiopathic dilated cardiomyopathy Res. 45:860-5. (2000)
  68. Barrientos A. and Moraes C.T. Titrating the effects of mitochondrial complex I impairment in the cell physiology Biol. Chem. 274:16188-97. (1999)
  69. Miró O., Barrientos A., Alonso J.R., Casademont J., Jarreta, D. Urbano-Márquez, A., and Cardellach F. Effects of general anaesthetic procedures on mitochondrial function of human skeletal muscle J. Clin. Pharmacol. 55(1):35-41. (1999)
  70. Biarnes J., Barrientos A., Ricart W., Nunes V., Fernandez-Castaner M., and Soler J. [Diabetes mellitus associated with the A3243G mutation of mitochondrial DNA. Apropos a case] Clin. (Barc) 112(3):99-101. (1999)
  71. Gomez Zaera M., Barrientos A., Arias L., Rojas I., Arruga J., Estivill X., Casademont, J., Nunes, V. [An analysis of 6 Leber mutations in 31 individuals with optic atrophy. A study of its transmission in 5 families] Clin. (Barc) 112:326-329. (1999)
  72. Miró O., Jarreta D., Casademont J., Barrientos A., Rodríguez B., Gomez M., Nunes V., Urbano-Márquez A. and Cardellach F. Absence of mitochondrial dysfunction in polymyalgia rheumatica. Evidence based on a simultaneous molecular and biochemical approach J. Rheumatol. 28(5):319-23 (1999)
  73. Barrientos A and Moraes C.T. Simultaneous transfer of mitochondrial DNA and single chromosomes in somatic cells: a novel approach for the study of defects in nuclear-mitochondrial communication Mol. Genet. 7: 1801-1808 (1998)
  74. Barrientos A., Kenyon L. and Moraes C.T. Human xenomitochondrial cybrids: cellular models of mitochondrial complex I deficiency Biol. Chem. 273: 14210-14217. (1998)
  75. Masanés F., Barrientos A., Cebrian M., Pedrol E., Miró O., Casademont J., and Grau J.M. Clinical, histological and molecular reversibility of zidovudine myopathy Neurol. Sci. 159: 226-228. (1998)
  76. Barrientos A., Marín C., Miró O., Casademont J., Gómez M., Nunes V., Tolosa E., Urbano-Márquez A., and Cardellach F. Biochemical and molecular effects of chronic haloperidol administration on brain and muscle mitochondria of rats Neurosci. Res. 53: 475-481. (1988)
  77. Miró O., Casademont J., Barrientos A., Urbano-Márquez A., and Cardellach F. Mitochondrial cytochrome c oxidase inhibition during acute carbon monoxide poisoning Toxicol. 82: 199-202. (1998)
  78. Miró O., Cardellach F., Barrientos A., Casademont, J., Rötig A., and Rustin P. Cytochrome c oxidase assay in minute amount of human skeletal muscle mitochondria using simple wavelength spectrophotometers J Neurosci Methods. 80: 107-111. (1998)
  79. Chretien D., Gallego J., Barrientos A., Casademont J., Cardellach F., Rötig A., Munnich A. and Rustin, P. Biochemical parameters for the diagnosis of respiratory chain deficiency in humans and their lack of age-related changes J. 329: 249-254 (1998)
  80. Barrientos A., Casademont J., Cardellach F., Estivill X, Urbano-Márquez A., and Nunes V. Reduced steady-state levels of mitochondrial RNA and increased mitochondrial DNA amount in human brain with ageing Brain Res. 52: 284-289(1997)
  81. Barrientos A., Casademont J., Cardellach F., Ardite E., Estivill E., Urbano-Márquez A., Fernández-Checa J.C. and Nunes V. Qualitative and quantitative changes in skeletal muscle mtDNA and expression of mitochondrial-encoded genes in the human aging process Mol. Med. 62, 165-171 (1997)
  82. Barrientos A., Casademont J., Genís D., Cardellach F., Fernández-Real J. M., Grau J.M., Urbano-Márquez A., Estivill X. and Nunes V. Sporadic heteroplasmic single 5.5 Kb mitochondrial DNA deletion associated with cerebellar ataxia, hypogonadotropic hypogonadism, choroidal dystrophy, and mitochondrial respiratory chain complex I deficiency Mut. 10: 212-216 (1997)
  83. Conget I., Barrientos A., Manzanares J.M., Casademont J., Viñas O., Barceló J., Nunes V., Gomis R. and Cardellach, F. Respiratory chain activity and mitochondrial DNA content of non-purified and purified pancreatic islet cells Metabolism 46: 984-987(1997)
  84. Barrientos A., Casademont J., Rötig A., Miro O., Urbano-Marquez A., Rustin P., and Cardellach F. Absence of relationship between the level of electron transport chain activities and ageing in human skeletal muscle Biophys. Res. Commun. 229: 536-539 (1996)
  85. Barrientos A., Casademont J., Saiz A., Cardellach F., Volpini V., Solans A., Tolosa E., Urbano-Márquez A., Estivill X., and Nunes V. Autosomal recessive Wolfram syndrome associated with a 8.5-kb mtDNA single deletion J. Hum. Genet. 58: 963-970 (1996)
  86. Barrientos A., Volpini V., Casademont J., Genis D., Manzanares J.M., Ferrer I., Corral J., Cardellach F., Urbano-Márquez A., Estivill X., and Nunes V. A nuclear defect in the 4p16 region predisposes to multiple mitochondrial DNA deletions in families with Wolfram syndrome Clin. Invest. 97: 1570-1576 (1996)
  87. Casademont J., Barrientos A., Grau J.M., Pedrol E., Estivill X., Urbano-Márquez A. and Nunes V. The effect of zidovudine on skeletal muscle mtDNA in HIV-1 infected patients with mild or no muscle dysfunction Brain 119: 1357- 1364 (1996)
  88. Conget I., Manzanares J.M., Barrientos A., Cardellach F. and Gomis R. Coenzyme Q and insuline secretion in vitro Diabetes Res. Clin. Pract. 33: 135-136 (1996)
  89. Barrientos A., Casademont J., Grau J.M., Cardellach F., Montoya J., Estivill X., Urbano-Márquez A. and Nunes V. Progressive external ophtalmoplegia and Kearns-Sayre syndrome: a clinical and molecular study of 6 cases Clin. (Barcelona) 105: 180-184 (1995)
  90. Barrientos A., Casademont J., Solans A., Moral P., Cardellach F., Urbano-Márquez A., Estivill X., and Nunes V. The 9-bp deletion in region V of mitochondrial DNA: evidence of mutation recurrence Genet. 96: 225-228 (1995)
  91. Casademont I., Barrientos A., Cardellach F., Rötig A., Grau J.M., Montoya J., Beltrán B., Cervantes F., Rozman C., Estivill X., Urbano-Márquez A. and Nunes V. Multiple deletions in mtDNA in two brothers with sideroblastic anemia and mitochondrial myopathy and in their asymptomatic mother Mol. Genet. 3: 1945-1949 (1994)