Antoni Barrientos

Flavia (new tenure-track Assistant Professor of BMB) publishes on a novel mechanism of mitochondrial translation regulation

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Alba publishes in Cell Reports on the role of HIGD1A and HIGD2A on mitochondrial respiratory chain complex and supercomplex biogenesis

Alba publishes in Cell Reports on the role of HIGD1A and HIGD2A on mitochondrial respiratory chain complex and supercomplex biogenesis

Read the News is posted on InventUM.    https://physician-news.umiamihealth.org/protein-complex-assembly-mechanisms-shed-light-on-cellular-energy-plants/

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Hyun-Jung received a 2020 U.M. Medical Faculty Association Award for Best Research

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Dr. Flavia Fontanesi publishes in NAR

Dr. Flavia Fontanesi publishes in NAR

Flavia Fontanesi directed the work of  Jeffri-Noelle Mays and led a three-lab collaborative effort that resulted in the publication on a paper in Nucleic Acids Research. The paper, entitled “The mitoribosome-specific protein mS38 is preferentially required for synthesis of cytochrome c oxidase subunits” can be found at https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkz266/5436776 Authors: Jeffri-Noelle Mays, Yolanda Camacho-Villasana, Rodolfo Garcia-Villegas, Xochitl Perez-Martinez, Antoni […]

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Tania Perez receives the ASB Meeting Oral Presentation Award

Tania Perez receives the ASB Meeting Oral Presentation Award

Tania Perez recently attended the 2019 Meeting of the Association of Southeastern Biologists (ASB) where she completed an oral presentation titled “Investigating the Assembly Pathway for the Yeast Mitoribosomal Small Subunit” in the Cell and Molecular Biology category. She was awarded the Lafayette Frederick Underrepresented Minorities Scholarship–which supported her attendance of the conference. Furthermore, Tania […]

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Priyanka and Eva received AHA postdoctoral fellowship awards

Priyanka and Eva received AHA postdoctoral fellowship awards

Congrats to Dr. Eva Nyvltova and Dr. Priyanka Maiti, who received postdoctoral fellowships from the American Heart Association (AHA).

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Tania wins the Best poster presentation award at the ABRCMS 2018 Symposium

Tania wins the Best poster presentation award at the ABRCMS 2018 Symposium

Congratulations to Tania Perez, who did an outstanding job presenting her work on the assembly pathway of the small ribosomal subunit in the yeast Saccharomyces cerevisiae.

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Three-Lab collaborative effort to study Mitochondrial Supercomplexes

Three-Lab collaborative effort to study Mitochondrial Supercomplexes

The mitochondrial respiratory chain is organized in a dynamic set of supercomplexes (SCs). The COX7A2L protein is essential for mammalian SC III2+IV assembly. However, its function in respirasome (SCs I+III2+IVn) biogenesis remains controversial. To unambiguously determine the COX7A2L role, we generated COX7A2L-knockout (COX7A2L-KO) HEK293T and U87 cells. COX7A2L-KO cells lack SC III2+IV but have enhanced complex III steady-state levels, activity, […]

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The RNA Club at UM is back!

The RNA Club at UM is back!

Following a couple of years of rest, the RNA Club organized by Dr. Murray Deutscher (Department of Biochemistry and Molecular Biology) and Dr. Antoni Barrientos is back. The first presentation will take place on November 14, 2018. Title: “The human Obg-family GTPase GTPBP10 is required for mitochondrial ribosome maturation” Presenter: Dr. Priyanka Maiti; Introduction to the […]

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Priyanka reports the function of the human ObG-family GTPase GTPBP10 in mitochondrial ribosome maturation

Priyanka reports the function of the human ObG-family GTPase GTPBP10 in mitochondrial ribosome maturation

Most steps on the biogenesis of the mitochondrial ribosome (mitoribosome) occur near the mitochondrial DNA nucleoid, in RNA granules, which contain dedicated RNA metabolism and mitoribosome assembly factors. Here, analysis of the RNA granule proteome identified the presence of a set of small GTPases that belong to conserved families of ribosome assembly factors. We show […]

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Hyun-Jung describes the function of the GTPase MTG1 in mitochondrial ribosome biogenesis

Hyun-Jung describes the function of the GTPase MTG1 in mitochondrial ribosome biogenesis

Mammalian mitochondrial ribosomes (mitoribosomes) synthesize 13 proteins, essential components of the oxidative phosphorylation system. They are linked to mitochondrial disorders, often involving cardiomyopathy. Mitoribosome biogenesis is assisted by multiple cofactors whose specific functions remain largely uncharacterized. Here, we examined the role of human MTG1, a conserved ribosome assembly guanosine triphosphatase. MTG1-silencing in human cardiomyocytes and […]

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Rui Zeng and Hyun-Jung Kim graduated

Rui Zeng and Hyun-Jung Kim graduated

Rui Zeng and Hyun-Jung Kim, two graduate students from the Biochemistry and Molecular Biology program at the University of Miami have graduated. Congratulations! Rui is already in China following postdoctoral training. Hyun-Jung will start in Novembre 2018 at Stanford University (CA).

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Rui publishes the first yeast mitoribosome assembly map

Rui publishes the first yeast mitoribosome assembly map

Mitoribosomes are specialized for the synthesis of hydrophobic membrane proteins encoded by mtDNA, all essential for oxidative phosphorylation. Despite their linkage to human mitochondrial diseases and the recent cryoelectron microscopy reconstruction of yeast and mammalian mitoribosomes, how they are assembled remains obscure. Here, we dissected the yeast mitoribosome large subunit (mtLSU) assembly process by systematic genomic […]

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Alba and Eva published a review on mammalian CIV biogenesis

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Andrea has been awarded with the HDSA HD Human Biology Project Fellowship

Andrea has been awarded with the HDSA HD Human Biology Project Fellowship

Andrea Ruetenik, Ph.D.candidate in the program of Neuroscience at the University of Miami Miller School of Medicine has been elected as one of the Huntington’s Disease Society of America (HDSA)’s 2018 Human Biology Project Fellows. Her proposal entitled “The protective role of NAD salvage pathway proteins against mutant huntingtin toxicity” received a two-years funding.

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A collaborative effort to decipher the role of the helicase Mss116 in mitochondrial ribogenesis and translation

A collaborative effort to decipher the role of the helicase Mss116 in mitochondrial ribogenesis and translation

Several members of our group (Dasmanthie De Silva, Sarah Poliquin, Rui Zeng, Natalie Marrero, Flavia Fontanesi and Antoni Barrientos) in collaboration with the group of Dr. Xochitl Perez Martinez have reported that Mss116 plays an important role in COX1 mRNA translation in S. cerevisiae by interacting with the COX1 mRNA translational activator Pet309. The article […]

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