Antoni Barrientos, Ph.D., professor of neurology, has received a highly prestigious Maximizing Investigators’ Research Award (MIRA), or R35 award, from the National Institute of General Medical Sciences (NIGMS), part of the National Institutes of Health. The five-year grant, totaling more than $4.5 million, consolidates three RO1 awards and gives Barrientos the status of “NIH investigator.” […]
The main research interest of our lab is on the basic mechanisms that govern the biogenesis of mitochondrial protein complexes in health, disease and aging. We are most specifically interested in the assembly and function of the mitochondrial translation machinery and of the mitochondrial respiratory chain and oxidative phosphorylation system components, involved in biological energy transduction. The study of mitochondria is now a very “hot issue” for both basic and clinical research. Mitochondria are not only the “energy factories” of the cell but they also house a multiplicity of pathways that serve to regulate cellular life and death. Importantly, mitochondria are involved in prevalent human diseases of wide social impact, most notably neurodegenerative disorders, but also in cancer and the aging process. Read More
We used yeast and fly models of polyglutamine diseases to study how enhancement of mitochondrial function affords suppression of polyglutamine-induced cytotoxicity in the context of stress and aging.